Board Thread:Questions and Answers/@comment-4923787-20131005001125/@comment-32656-20131127130918

If it gets all of them, it screws the idea. At one point or another, Venice held most of the Greek areas, which would invalidate the whole concept. If you're just meaning its island possessions, it makes things harder, but not impossible. Retaking, however, would be hard at best, and would need Venice on the losing side of some sort of war in Italy.

By the time artillery gets strong enough to threaten the city from the other side, you're talking centuries after they were first used in battle in Europe. Not moving anywhere.