Board Thread:Questions and Answers/@comment-6876762-20130303211712/@comment-1789156-20130402145056

It's probably unlikely that any horses or livestock would have survived. As for disease spreading, using modern knowledge we can look back at the severity of the disease. Maybe by coincidence the inital outbreak isn't as devasting if it is contained, but that is just delaying the inevitable.

It's not unlikely that any surviving Spanish could have tried to marry and live with the natives. For example the mutineers from the HMS Bounty are famous for settling Pitcairn Island with only six men, eleven female natives, and a baby. Today Pitcairn Island is an overseas territory of the United Kingdom.