Timeline (Pukayana)

1300s

 * ~1350: The first person is infected by Pukayana.
 * ~1352: Healing techniques begin to develop in the affected regions (Andes)
 * ~1367: All time low for New World population for several hundred years, with nearly 50% of the population of the entire continent dying.
 * ~1370: Pukayana reaches OTL Canada.
 * ~1390: Healing techniques start to become perfected, the New World population growth starts to increase much faster.

1400s

 * 1400: By this time, most New World civilizations have invested lots of money into sanitation. For example, the Aztecs have implemented advanced sewer systems into their largest cities.
 * ~1440: New World population finally reaches back to old levels.
 * 1463: The Aztecs defeat the Tlaxcalteca due to having a higher population in this timeline. The Aztec Empire's growth is faster than in OTL.
 * ~1470: Another wave of Pukayana rocks the New World, but with only 20% of the population being killed off.
 * 1490: By this time, several powerful native civilizations have overcame and annexed smaller, greatly weakened tribes and consolidated their lands.
 * 1492: Christopher Columbus reaches the New World. Before he can sail back, the Ciguayos manage to sabotage and severely damage the Niña, although the Pinta remains intact enough to sail. Columbus manages to escape, but a storm in the Atlantic finishes the Pinta, sinking it.
 * 1493: The rulers of Spain, Queen Isabella and King Ferdinand declare that Columbus has died.
 * 1498: During the second Battle of the Maule, the Inca decisively defeat the Purumaucas and their allies. The southward expansion of the Incan empire resumes, although there is no expansion of the north side.