There are multiple PoDs that are involved with this timeline. The first starts in Guelders, instead of Charles II of Guelders dying childless, what if he had a daughter to inherit his Dukedom? What if this daughter married William the Rich, the brother of Anne of Cleves? What if their daughter happened to be in England while an extremely healthy 18-year-old Edward VI was looking for a wife? Shall the Tudor Rose bloom? Edward VI living to old age has some interesting effects on the world at large.
Under Henry VII
Queen Anne Neville is still alive when Richard III goes to battle the Earl of Richmond. Her husband is killed in battle as in OTL. She is taken prisoner by Henry VII's army and like many of the Yorkist women, she is married off to one of Henry's supporters, Richard Woodville, Earl Rivers. She is known at court only as Lady Rivers or the Princess Dowager of Wales, and it never acknowledged that Richard III was ever king. She brings the Neville fortune to the Woodville family and after the execution of Edward Plantagenet, the title of Earl of Warwick. Her sons would go on to be valued members of Henry VIII's court and the Woodville family would amass wealth, land, and titles.
Under Henry VIII
In 1536, Anne Boleyn gives Henry VIII the long-desired son, Henry, Prince of Wales. She is able to save her head and returns to Henry's affections. She quickly falls pregnant again. With her husband back under her influence, she is able to convince Henry to marry off his daughter with Catherine of Aragon to her younger brother, Thomas Boleyn. Henry is hesitant at first, but Anne assures him that this will make Mary recognize him as head of the church and bring her closer to him once more. Thomas is raised to Duke of Hereford and is wed to Mary. There are three children produced from the marriage, but only two daughters survive. Anne Boleyn delivers a second son, Edward, Duke of York. Queen Anne dies shortly after the birth. Henry is heartbroken at her death, but Jane Seymour reveals she is pregnant with his child. He quickly marries her in case it is another son, but it is a daughter, named Jane. Jane Seymour dies shortly after this. Henry mourns. In 1539, Henry, Prince of Wales dies, leaving Henry with only one son. Lady Mary and Thomas Boleyn present Henry with his first grandchild, Lady Catherine Boleyn, later that year. Thomas Cromwell negotiates the Cleves marriage and Anne of Cleves sails to England, accompanied by her sister-in-law, Sophia of Guelders. Sophia is coming to England to negotiate a marriage contract between Edward and her daughter Amalia. Henry met them at Rochester, dressed in disguise, and kissed the Duchess of Guelders. Both Anne and Sophia were shocked at this, and Henry was clearly embarrassed. The marriage went ahead and the betrothal between Edward and Amalia of Cleves was drawn up. Anne and Henry enjoyed a friendly relationship, though Henry wasn't quite attracted to her. He and Anne manage to conceive a son, William, that dies shortly after birth. Henry annuls the marriage to Anne in favor of the young, vital Catherine Howard. George Boleyn is sent off to France to negotiate a marriage between Charles II de Valois and Princess Elizabeth. His wife, Jane Parker, joins the new queen's household. It is discovered that Queen Catherine is having an affair with Thomas Culpepper and Jane Parker was concealing it. Jane Parker is executed alongside her queen. George Boleyn returns to England, failing to secure a proper marriage contract that Henry would agree to. George then remarries to Elizabeth Stafford. Henry decides to break the betrothal to Amalia of Cleves in favor of Mary, Queen of Scots. The Rough Wooing ensues as in OTL. Henry's reign concludes as it did in OTL. However, the line of succession is now: Edward, Elizabeth, Jane, and then the Lady Mary.
Edward VI becomes King of England in 1547. George Boleyn is in Vienna when Henry VIII died, allowing for Edward and Thomas Seymour to take over the regency council. The Duke of Hereford is banished from court and returns to his estate with his wife and two daughters. Thomas Seymour and Catherine Parr marry and take custody of Princess Elizabeth, Princess Jane, and Lady Jane Grey. The Lady Mary encourages her husband to return to court and try to get influence over the young Edward. He refuses. George Boleyn is then ordered to Ireland by the Seymour brother, where he goes with his wife and children. The Seymour brothers have control over the council until Catherine Parr's death. Upon her death, Thomas Seymour starts to court marriage to Princess Elizabeth. This is seen as treason and is acted upon more quickly in ATL. The Duke and Duchess of Hereford take the young princesses and Lady Jane Grey into their household as the investigation takes place. Both Elizabeth and Jane are questioned by Anthony Woodville. Princess Jane gives information that breaks Elizabeth's evasive answers. Elizabeth and Jane are imprisoned in the Tower of London by Edward Seymour to be questioned further about any possible pre-contract between Elizabeth and Thomas Seymour. Edward Seymour questions Elizabeth, who denies having made any pre-contract with Thomas Seymour. Thomas Seymour is executed and Elizabeth is released to Thomas Boleyn. Princess Jane is kept in the tower a bit longer to ensure that she was not to be used as a pawn by the Seymours for the throne. The regency council meet without the protector and conspire to oust Edward Seymour from the regency council.