There are multiple PoDs that are involved with this timeline. The first starts in Guelders, instead of Charles II of Guelders dying childless, what if he had a daughter to inherit his Dukedom? What if this daughter married William the Rich, the brother of Anne of Cleves? What if their daughter happened to be in England while an extremely healthy 18-year-old Edward VI was looking for a wife? Shall the Tudor Rose bloom? Edward VI living to old age has some interesting effects on the world at large.
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