In 1492, Christopher Columbus went to the court of Isabella of Castile and Ferdinand of Aragon, asking for help in an enterprise to sail west and reach the Indies. The King and Queen are not convinced, and Columbus leaves for France where his luck is no better.
The discovery of Cabotia
In 1497, Italian explorer John Cabot led an expedition to Asia and disembarked in the land currently known as Cabotia (OTL North America), and claimed it for England. A second expedition led by Cabot was lost.